Skip to content
Important Legal Disclaimer: This is an off-label use of botulinum toxin; no results are ever guaranteed (no therapy works every time). If considered, it should only be done by a physician who has been properly trained and certified to do the procedure and only after considering all other options, including the option to do nothing, and only after a signed consent that includes the fact that results may vary and are unpredictable for new, off-label therapy and includes all the usual contraindications and possible side effects of botulinum toxin.
Summary of Mechanism of Action…
After Injecting botulinum neurotoxin (BoNT) into the clitoris, it is thought that (1) it is taken up by endocytosis and then migrates by axonal transport to the ganglion embedded in the wall of the vagina; (2) these ganglia then signal (through afferent autonomic nerves in the inferior hypogastric plexus) to trigger the hypothalamus (where the arousal center resides); (3) the activated hypothalamus triggers (through efferents going back to the genitalia and to the cerebral cortex) arousal, desire, and lubrication, and facilitate orgasm, combining to increase sexual satisfaction in the woman. This is in addition to the neovascularization, neurogenesis, and local vasodilation triggered by the BoNT. These effects can be amplified when the BoNT is combined with the regenerative properties of platelet-rich plasma. Here’s the original research by Runels and Runnels supporting these ideas (click to read).